Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%‡
Vitamin C (as Ascorbic Acid & Sodium Ascorbate)
60 mg
67%
Vitamin B-6 (as Pyridoxine HCl)
5 mg
294%
Zinc (as Zinc Aspartate)
15 mg
136%

Top Medical Research Studies

9
Vitamin C impacts autoimmune response
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.

Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.

In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More

Most Useful Reviews

9
Effective treatment
8 people found this helpful
I used this drug when I first experienced a sore throat in November. I followed the instructions and took 4 capsules on the first day. The next day, I was delighted as my sore throat had disappeared. I completed the course over 6 days, which I highly recommend. The tablets are for resorption, not for chewing.
Read More
7.5
Boosted immune system
3 people found this helpful
This zinc supplement with vitamins C and B6, featuring a pleasant cherry flavour, is excellent for my immune system, particularly in winter and transitional seasons. I appreciate the 15 mg dosage in these chewable tablets and the good volume of 90 tablets. I only take up to 6 a day, which I find highly effective. I will definitely order more!
Read More
2
No results noted
I ordered this for my mother, but unfortunately, she did not notice any improvement. Perhaps the product's formula wasn't suitable for her.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.9
  • All Researches
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.

What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
9
Vitamin C impacts autoimmune response
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C aids rheumatoid arthritis treatment
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.

Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.

We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.

In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Read More
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.

Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.

In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective treatment
8 people found this helpful
I used this drug when I first experienced a sore throat in November. I followed the instructions and took 4 capsules on the first day. The next day, I was delighted as my sore throat had disappeared. I completed the course over 6 days, which I highly recommend. The tablets are for resorption, not for chewing.
Read More
7.5
Boosted immune system
3 people found this helpful
This zinc supplement with vitamins C and B6, featuring a pleasant cherry flavour, is excellent for my immune system, particularly in winter and transitional seasons. I appreciate the 15 mg dosage in these chewable tablets and the good volume of 90 tablets. I only take up to 6 a day, which I find highly effective. I will definitely order more!
Read More
2
No results noted
I ordered this for my mother, but unfortunately, she did not notice any improvement. Perhaps the product's formula wasn't suitable for her.
Read More

Frequently Asked Questions

9
Effective treatment
8 people found this helpful
I used this drug when I first experienced a sore throat in November. I followed the instructions and took 4 capsules on the first day. The next day, I was delighted as my sore throat had disappeared. I completed the course over 6 days, which I highly recommend. The tablets are for resorption, not for chewing.
2
No results noted
I ordered this for my mother, but unfortunately, she did not notice any improvement. Perhaps the product's formula wasn't suitable for her.
7.5
Boosted immune system
3 people found this helpful
This zinc supplement with vitamins C and B6, featuring a pleasant cherry flavour, is excellent for my immune system, particularly in winter and transitional seasons. I appreciate the 15 mg dosage in these chewable tablets and the good volume of 90 tablets. I only take up to 6 a day, which I find highly effective. I will definitely order more!
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
4
Zinc intake influences autoimmune risk
We examined the connection between dietary zinc intake and the risk of autoimmune thyroiditis (AIT), particularly focusing on Hashimoto's thyroiditis. The study analyzed data from the 2007-2008 National Health and Nutrition Examination Survey, including nearly 5,500 participants—273 with AIT and 5,194 without it.

Our findings revealed that higher dietary zinc intake is associated with an increased risk of AIT, acting as an independent risk factor. This is concerning, as excessive zinc could disrupt our immune balance, potentially leading to other autoimmune disorders.

While it’s clear that zinc plays a role in thyroid health, we must be cautious about how much we consume. The study suggests that dietary zinc should be carefully monitored in those at risk for AIT, and it highlights the need for further research to establish safe consumption levels.
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
8
Zinc's role in alopecia areata
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.

The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.

Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.

References

  1. Shao Y, Mu Q, Wang R, Luo H, Song Z, et al. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. Sci China Life Sci. 2025. doi:10.1007/s11427-024-2817-y
  2. Chen L, Yan C, Huang C, Jiang Z, Lin R, et al. Higher dietary zinc intake increases the risk of autoimmune thyroiditis. Postgrad Med J. 2025. doi:10.1093/postmj/qgae202
  3. Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
  4. Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540
  5. Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5
  6. Cheng J, Rink L, Wessels I. Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4. Mol Nutr Food Res. 2024;68:e2400013. doi:10.1002/mnfr.202400013
  7. Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, et al. Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis. Food Funct. 2025;16:673. doi:10.1039/d4fo03096f
  8. Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. doi:10.1017/S0007114524001715
  9. Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. doi:10.1186/s12964-024-01756-x
  10. Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, et al. Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int J Mol Sci. 2024;25. doi:10.3390/ijms25137284
  11. Ali A, Jori C, Kumar A, Vyawahare A, Kumar J, et al. A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis. Biomater Sci. 2024;12:3389. doi:10.1039/d4bm00243a
  12. Zhang Y, Zhen S, Xu H, Sun S, Wang Z, et al. Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. Biosci Trends. 2024;18:187. doi:10.5582/bst.2024.01037
  13. Zhang L, Li G, Lin B, He H, Zhou R, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome. Int Immunopharmacol. 2024;131:111915. doi:10.1016/j.intimp.2024.111915
  14. Santiworakul C, Saisorn W, Siripen N, Leelahavanichkul A, Rianthavorn P. Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency. Pediatr Nephrol. 2024;39:1135. doi:10.1007/s00467-023-06189-1
  15. Mungan S, Guzel I, Demirdogen BC. Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis. Braz J Med Biol Res. 2023;56:e12776. doi:10.1590/1414-431X2023e12776
  16. Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab. 2023;6:e432. doi:10.1002/edm2.432
  17. Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, et al. Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep. 2023;7:302. doi:10.1093/mrcr/rxac059
  18. Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. doi:10.1111/jcmm.15917
  19. Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. doi:10.5582/ddt.2020.03031
  20. Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. doi:10.1016/j.msard.2020.102132
  21. Sande JS, Ulvik A, Midttun Ø, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. J Nutr. 2019;149:770. doi:10.1093/jn/nxz001
  22. Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. doi:10.1111/j.1756-185X.2011.01679.x
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